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本研究在动脉粥样硬化（ＡＳ）和冠心病（ＣＨＤ）高发区（北京）、低发区（南宁），于１９８６年～１９８９年间，共收集了意外死亡年轻人（１５～３９岁）新鲜尸检标本３２４例。用形态测量和生化分析的方法研究了两地同龄年轻人主动脉内膜脂质浸润、内膜厚度、平滑肌细胞（ＳＭＣ）和基质中蛋白聚糖（ＰＧｓ）的变化以及地区差异，以探索其与ＡＳ发生发展的关系，为ＡＳ的防治提供依据。主要结果：主动脉内膜ＳＭＣ核的密度尤其面积密度均是北高于南（Ｐ＜０．０１）。ＳＭＣ核密度与同组切片阿新蓝染色阳性物质量呈负相关；同组标本的生化分析ＰＧｓ总量和有抑制ＳＭＣ增殖的ＨＳ－ＰＧ含量均北低于南（Ｐ＜０．０１）；主动脉内膜脂质浸润的嗜苏丹病变（ＳＬ），除男性腹主动脉ＳＬ面积百分比北高于南（Ｐ＜０．０１）外，两地接近。上述结果提示有抑制ＳＭＣ增殖的ＨＳ－ＰＧ含量降低可能为北京主动脉内膜ＳＭＣ增殖的原因之一，还提示随南宁地区近年来人群血情胆固醇水平上升，在主动脉内膜ＳＬ已有所反映，这一变化趋势从预防ＡＳ或ＣＨＤ角度应引起注意。
In this study, young people (15-39 years old) died of accidental death were collected from 1986 to 1989 in high incidence area of atherosclerosis (AS) and coronary heart disease (CHD) and low incidence area (Nanning) Autopsy specimens of 324 cases. The changes of aortic intima-media thickness, intima-media thickness, smooth muscle cell (SMC) and matrix proteoglycan (PGs) and regional differences in young men of the same age were studied by morphological measurement and biochemical analysis. And the occurrence and development of AS, providing the basis for the prevention and treatment of AS. MAIN RESULTS: The density, especially the area density, of the aortic intimal SMC nucleus was higher in the north than in the south (P <0.01). The nuclear density of SMC was negatively correlated with the amount of alcianosine positive cells in the same group. The biochemical analysis of the same group of biochemical samples showed that the total amount of PGs and the content of HS-PG with inhibition of proliferation of SMC were lower than those in the south (P <0.01). Atherosclerosis-like lesions (SL) in the aortic intima were similar in both regions except that the area of SL in the abdominal aorta was higher in the north than in the south (P <0.01). The above results suggest that the inhibition of SMC proliferation of HS-PG content may be one of the reasons for the proliferation of Beijing aortic intima SMC, but also prompted with the Nanning region in recent years, blood cholesterol levels in the population increased in the aorta SL has been This trend reflects the need to prevent AS or CHD.