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目的 探讨尿核基质蛋白 2 2 (NMP2 2 )水平改变对膀胱移行细胞癌 (BTCC)辅助诊断及复发监测的意义。方法 应用酶联免疫吸附试验 (EL ISA)检测 7例 BTCC患者 (其中术前 2例 ,术后 5例 )及 2例健康人尿NMP2 2。结果 BTCC患者术前尿 NMP2 2明显升高 ,敏感性 1 0 0 % ,术后随访肿瘤复发者明显上升 (>1 0 2 U/ ml) ,无复发者在正常范围 (<1 0 U/ ml)。结论 尿 NMP2 2检测方便、无创 ,可望成为 BTCC辅助诊断及术后监测的参考指标
Objective To investigate the significance of the change of NMP2 2 in the diagnosis and recurrence of transitional cell carcinoma of the bladder (BTCC). Methods Seven patients with BTCC (2 cases preoperatively and 5 postoperatively) and 2 cases of healthy human urine NMP2 2 were detected by enzyme linked immunosorbent assay (ELISA). Results The preoperative urinary NMP2 2 level in patients with BTCC was significantly higher than that in patients with BTCC, with a sensitivity of 100%. The recurrence rate of patients with BTCC increased significantly (> 102 U / ml) ). Conclusion Urine NMP2 2 is convenient and noninvasive, which is expected to become a reference index for the diagnosis and postoperative monitoring of BTCC