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[目的]了解四川地区产前筛查的现状。[方法]在孕中期(孕15-20周)采血检测孕妇血清中甲胎蛋白(AFP)、人游离β-绒毛膜促性腺激素(f-βhCG)和游离雌三醇(μE3)(我觉得我们医院也一起用了游离雌三醇,我明天上门诊时看一下报告单)值,检测结果结合孕妇年龄、孕周、体重、是否双胎、有无糖尿病及吸烟史等因素,利用风险评估软件计算21-三体、18-三体综合征和开放性神经管缺陷的风险概率。[结果]3年间四川地区孕妇总产前筛查率为5.08%,高危孕妇和低危孕妇的总筛查阳性率分别为23.68%和8.59%。21-三体、18-三体、开放性神经管缺陷在高危孕妇中的筛查阳性率分别为21.46%、0.96%、1.26%,在低危孕妇中分别为7.34%、0.13%、1.11%。[结论]产前筛查作为先天畸形的二级干预措施,在降低先天畸形发生方面有重要作用,但目前四川地区的产前筛查率仍较低,需进一步普及。
[Objective] To understand the status of antenatal screening in Sichuan. [Methods] AFP, human free β-chorionic gonadotropin (f-βhCG) and free estriol (μE3) were detected in the second trimester of pregnancy (15-20 weeks pregnant) Our hospital also used free estriol together, and I will see the report card when going to the clinic tomorrow. The test results combined with the factors such as the age of pregnant women, gestational age, weight, twins, diabetes mellitus and smoking history, The software calculates the risk odds of trisomy 21, trisomy 18 and open neural tube defects. [Results] The prenatal screening rate of pregnant women in Sichuan was 5.08% in three years. The positive rates of screening for high-risk pregnant women and low-risk pregnant women were 23.68% and 8.59% respectively. 21.46%, 0.96%, 1.26% of 21- trisomy, 18- trisomy and open neural tube defects in high-risk pregnant women were 7.34%, 0.13%, 1.11% . [Conclusion] Prenatal screening as a secondary intervention for congenital malformations plays an important role in reducing the incidence of congenital malformations. However, the prenatal screening rate in Sichuan is still low and needs to be further popularized.