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目的:探讨六味地黄丸治疗围绝经期干眼症的临床疗效,对其作用机制进行初步探讨。方法:将86例围绝经期干眼症患者随机分为观察组和对照组各43例。对照组患者采用玻璃酸钠滴眼液治疗,每天3次,持续4周;观察组患者在对照组的基础上加服六味地黄丸治疗。比较两组患者的临床疗效以及角膜荧光素染色、基础泪液分泌实验、泪膜破裂时间等情况。结果:经过治疗,两组患者临床症状均有所改善,且观察组患者各指标改善情况均显著优于对照组,差异具有统计学意义(P<0.05)。结论:采用玻璃酸钠滴眼液联合六味地黄丸治疗围绝经期干眼症可明显改善患者不适症状,其作用机制可能与调节激素水平有关。
Objective: To investigate the clinical efficacy of Liuweidihuangwan in the treatment of perimenopausal dry eye and to explore its mechanism. Methods: 86 cases of climacteric dry eye patients were randomly divided into observation group and control group, 43 cases each. Patients in the control group were treated with sodium hyaluronate eye drops 3 times a day for 4 weeks. Patients in the observation group were given Liuweidihuang Pills on the basis of the control group. The clinical efficacy, corneal fluorescein staining, basal tear secretion test and tear film rupture time were compared between the two groups. Results: After treatment, the clinical symptoms of both groups were improved, and the improvement of each index in the observation group was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion: Sodium hyaluronate eye drops combined with Liuweidihuang Pill can significantly improve the symptoms of patients with peri-menopausal dry eye. The possible mechanism may be related to the regulation of hormone levels.