论文部分内容阅读
分别用东莨菪碱与反复缺血再灌注制备阿尔采末病 (AD)与血管性痴呆 (VD)模型 ,考察当归芍药散 (DSS)防治老年期痴呆的配伍机理。避暗法与跳台法检测发现 ,AD组较正常组潜伏期缩短 (P <0 .0 1) ,错误次数增多 (P <0 .0 5～ 0 .0 1) ;VD组较假手术组潜伏期缩短 (P <0 .0 1) ,错误次数增多 (P <0 .0 1) ,DSS中活血补血药组 (DCS)与健脾利湿药组 (FBZ)可协同延长AD小鼠潜伏期 ,减少错误次数 (P <0 .0 5～ 0 .0 1) ;对VD小鼠 ,仅FBZ可延长潜伏期 (P <0 .0 5 ) ,减少错误次数 (P <0 .0 1) ,提示FBZ较DCS可能具有更大的防治意义。
The model of Alzheimer’s disease (AD) and vascular dementia (VD) were prepared with scopolamine and repeated ischemia-reperfusion respectively to investigate the compatibility mechanism of Danggui Shaoyao San (DSS) in preventing and treating senile dementia. The evasion detection method and the step-down method found that the AD group had shorter latency (P < 0.01) than the normal group, and the number of errors increased (P <0.05-0.01); the VD group had shorter latency than the sham group. (P <0. 0 1), the number of errors increased (P <0.01). The blood stasis group (DCS) and the spleen-dried dampness group (FBZ) in DSS can synergistically prolong the latency of AD mice and reduce errors. Frequency (P <0.05 ~ 0.01); For VD mice, FBZ only prolonged the incubation period (P <0.05) and reduced the number of errors (P <0.01), suggesting that FBZ was more frequent than DCS. May have greater control significance.