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目的探讨大剂量静脉注射免疫球蛋白 (IVIG)对毛细支气管炎患儿的疗效和防止病愈后反复喘息发作的方法。方法临床诊断毛细支气管炎 2 13例 ,按随机原则 ,分对照组和大剂量 IVIG组 ,大剂量 IVIG组 ,每次 IVIG 1g/ kg,连用 2天。观察疗效 ,病愈后对其随访。结果大剂量 IVIG组可明显缩短入眠达正常时间 ,吸氧时间、哮鸣音消失时间及住院时间 ,与对照组比较有显著性差异 (P<0 .0 1)。随访 195例 ,发生反复喘息 ,对照组占 5 3 .7% ,大剂量 IVIG组占 2 8.1% ,有显著性差异 (P<0 .0 1)。结论大剂量 IVIG对毛细支气管炎急性期有确实疗效 ,并能减少病愈后反复喘息发作
Objective To investigate the curative effect of high dose intravenous immunoglobulin (IVIG) on children with bronchiolitis and the method of preventing recurrent wheezing after recovery. Methods Two hundred and thirteen cases of bronchiolitis were diagnosed clinically. According to the principle of randomness, the rats in control group, high dose IVIG group and high dose IVIG group were treated with IVIG 1g / kg once daily for 2 days. Observation of efficacy, after the recovery of their follow-up. Results High-dose IVIG group could significantly reduce the normal time to sleep, oxygen inhalation time, disappearance of wheeze and hospital stay, compared with the control group were significantly different (P <0.01). A total of 195 cases were followed up for wheezing, with the control group accounting for 53.7% and the high-dose IVIG group accounting for 21.1% (P <0.01). Conclusion High-dose IVIG has a definite curative effect on the acute stage of bronchiolitis, and can reduce repeated episodes of wheezing after recovery