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目的观察双联抗血小板在治疗非心源性缺血性脑卒中的临床疗效。方法选取医院2014年3月-2015年6月收治符合非心源性缺血性脑卒中诊断标准患者70例,随机分为观察组和对照组各35例。对照组给予阿司匹林药物治疗,观察组在对照组的基础上给予氯吡格雷治疗,分析比较2组治疗疗效。结果观察组治疗治愈率和总有效率为57.1%和85.7%明显高于对照组的37.2%和68.6%,差异有统计学意义(P<0.05);观察组的血浆黏度、血小板聚集率、全血低切黏度3项指标明显低于对照组,差异有统计学意义(P<0.05);在纤维蛋白原变化对比中,差异无统计学意义(P>0.05)。结论双联抗血小板在治疗非心源性缺血性脑卒中效果显著,可改善临床各项指标,缓解症状,在临床应用中值得推广。
Objective To observe the clinical efficacy of dual antiplatelet in the treatment of non-cardiac ischemic stroke. Methods Seventy patients with non-cardio-ischemic stroke admitted to our hospital from March 2014 to June 2015 were randomly divided into observation group (35 cases) and control group (35 cases). The control group was given aspirin, and the observation group was treated with clopidogrel on the basis of the control group. The therapeutic effects were compared between the two groups. Results The cure rate and total effective rate of observation group were 57.1% and 85.7%, respectively, which were significantly higher than that of control group (37.2% and 68.6%, P <0.05). The observation group’s plasma viscosity and platelet aggregation rate The indexes of blood low shear viscosity were significantly lower than those of the control group (P <0.05). There was no significant difference in the changes of fibrinogen (P> 0.05). Conclusion Dual antiplatelet therapy is effective in treating non-cardiac ischemic stroke, which can improve clinical indexes and relieve symptoms, which is worthy of promotion in clinical application.