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目的:探讨益经汤对去势雌性大鼠体重和血脂的影响。方法:大鼠分为模型组和假手术组,模型组大鼠结扎切除卵巢,假手术组大鼠手术暴露卵巢但不切除。造模成功后,随机分为假手术组、模型组、益经汤高剂量组(24 g/kg)、益经汤低剂量组(12 g/kg)、西药补佳乐组(0.09 mg/kg)。假手术组和模型组灌同等体积的生理盐水,每天1次,连续给药6周后,腹主动脉采血,分离血清测定总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平。实验大鼠随机分组后,称初重,手术4周后称重,采集标本前称终重。结果:模型组动物体重明显增加,与假手术组、益经汤高剂量组比较,差异有显著性(P<0.01);益经汤高剂量组在降低TC、LDL方面,与模型组相比差异有显著性(P<0.01)。结论:益经汤高低剂量组和西药补佳乐组可明显延缓去势雌性大鼠体重增长,益经汤高剂量组能够纠正去势雌性大鼠的脂代谢紊乱状态。
Objective: To investigate the effect of Yijing Decoction on body weight and blood lipids in ovariectomized female rats. Methods: The rats were divided into model group and sham group. Rats in the model group were ovariectomized and ovariectomized without surgery. After successful modeling, the rats were randomly divided into sham operation group, model group, Yijing Decoction high dose group (24 g / kg), Yijing Decoction low dose group (12 g / kg) kg). Sham-operation group and model group were injected with the same volume of normal saline once a day for 6 weeks. Blood samples were taken from the abdominal aorta and the contents of total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) level. After randomization, the rats were weighed and weighed after 4 weeks of operation. The final weight was taken before the specimens were collected. Results: Compared with model group, the body weight of model group increased significantly, compared with sham operation group and Yijing Decoction high dose group (P <0.01); Compared with model group, Yijing Decoction high dose group reduced TC and LDL The difference was significant (P <0.01). Conclusion: The Yijing Decoction high-dose group and western medicine Gagarin group can delay the body weight gain of ovariectomized female rats. Yijingjing high dose group can correct the disorders of lipid metabolism in ovariectomized female rats.