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自1851年Helmholtz发明眼底镜一百多年以来,仍然只能观察到一个“静止”的眼底;而且不少细微的病变即使用最现代化的眼底镜也不能够观察到。更不能观察到眼底血循环的动态表现。 1958年Chao和Flock第一次应用1％台盼兰溶液注入兔的颈动脉,用眼底镜观察眼底,以研究视网膜循环时间。同时提出了利用一些更无害的指示剂(例如荧光素)来研究人类视网膜疾患的设想。一年以后,开始用10％荧光素钠注射于猫的股静脉作眼底血管造影的动物实验。
Since Helmholtz invented the ophthalmoscope in 1851 for more than a century, only a “still” fundus has been observed; and many subtle lesions can not be observed with the most modern ophthalmoscope. Can not observe the dynamic manifestations of blood circulation. In 1958 Chao and Flock first application of 1% trypan blue solution into the rabbit’s carotid artery, fundus observation with fundus to study retinal circulation time. At the same time, the idea of using some of the more innocuous indicators (such as fluorescein) to study human retinal disorders has been proposed. One year later, an animal experiment of fundus angiography was started with 10% sodium fluorescein injection into the femoral vein of a cat.