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目的探讨桂枝茯苓胶囊联合子宫动脉栓塞术对中老年子宫肌瘤患者激素水平及治疗效果的影响。方法选择2013年6月-2014年6月112例中老年子宫肌瘤患者为研究对象,采用随机数字表法分为观察组和对照组各56例。对照组行子宫动脉栓塞术,观察组采用子宫动脉栓塞术联合桂枝茯苓胶囊治疗,比较两组性激素水平、临床症状、治疗效果。结果观察组有效率94.64%明显高于对照组80.36%(χ~2=5.224,P<0.05);子宫肌瘤体积、阴道出血量明显小于对照组,血红蛋白水平明显高于对照组(t=9.511、6.180、5.082,均P<0.05);血清雌二醇(E2)、孕酮(P)明显低于对照组,促卵泡激素(FSH)、黄体生成素(LH)明显高于对照组(t=4.552、2.671、9.158、5.692,均P<0.05)。结论桂枝茯苓胶囊联合子宫动脉栓塞术有助于缓解中老年子宫肌瘤患者临床症状,改善性激素水平,提高治疗效果。
Objective To investigate the effect of Guizhi Fuling Capsule combined with uterine arterial embolization on hormone levels and therapeutic effect of middle-aged and elderly patients with uterine fibroids. Methods From June 2013 to June 2014, 112 cases of middle-aged and elderly patients with uterine fibroids were divided into observation group and control group with 56 cases in each group. The control group received uterine artery embolization. The observation group was treated with uterine artery embolization combined with Guizhi Fuling capsule. The levels of sex hormones, clinical symptoms and therapeutic effects were compared between the two groups. Results The effective rate of observation group was 94.64%, which was significantly higher than that of control group (χ ~ 2 = 5.224, P <0.05). The volume of uterine fibroids and vaginal bleeding were significantly lower than those of control group, and hemoglobin level was significantly higher than that of control group (t = 9.511 , 6.180,5.082, all P <0.05). Serum estradiol (E2) and progesterone (P) were significantly lower than those of the control group. FSH and LH were significantly higher than those of the control group = 4.552,2.671,9.158,5.692, all P <0.05). Conclusion Guizhi Fuling capsules combined with uterine artery embolization can help alleviate the clinical symptoms of patients with uterine fibroids in the elderly, improve sex hormone levels and improve the therapeutic effect.