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目的：探讨鼻腔局部应用卡介菌多糖核酸（BCG‐PSN ）治疗儿童常年性变应性鼻炎（AR）的治疗效果。方法选取在该院治疗的A R患者166例，随机分为治疗组和对照组。治疗组83例，采用无痛的鼻腔负压置换，将BCG‐PSN稀释液留置于鼻窦治疗AR ，疗程5周；对照组83例，采用常规肌肉注射BCG‐PSN治疗AR ，疗程5周。结果对照组AR治疗后的症状记分、体征记分高于治疗前，差异有统计学意义（P＜0．05）；治疗组AR治疗后的症状记分、体征记分高于治疗前，差异有统计学意义（P＜0．05）；两组的治疗方法对于 AR均有疗效，治疗组的疗效更好，其有效率为85．9％，高于对照组68．75％，差异有统计学意义（P＜0．05）。结论鼻腔局部应用BCG‐PSN ，负压置换治疗儿童常年性AR安全，相比肌肉注射疗效更好，且便捷、舒适、痛苦小。“,”Objective To research the effect of nasal cavity local application of BCG polysaccharide nucleic acid (BCG‐PSN) for treating perennial allergic rhinitis(AR) in children .Methods 166 children patients with perennial AR in our hospital were selected and randomly divided into the treatment group and the control group ,83 cases in each group .The treatment group ,adopted painless nasal cavity negative pressure displacement for retaining BCG‐PSN dilution solution in the nasal sinuses to treat AR ,which lasted for 5 weeks .The control group was routinely given BCG‐PSN by intramuscular injection with the treatment course of 5 weeks .Results The symptom score and the physical sign scores after treatment in the control group were higher than those before treatment ,the differences were statistically significant(P<0 .05) .The symptom score and the physical sign score after treatment in the treatment group were higher than those before the treatment with statistical differences(P<0 .05) .The treatment methods in the two groups were effective ,but the treatment had better effect ,the effective rate in the treatment group was 85 .9% ,which was higher than 68 .75% in the control group ,to the difference was statistically significant(P<0 .05) . Conclusion The nasal cavity local application of BCG‐PSN and negative pressure displacement for treating children′s perennial AR is safe and has better effect than intramuscular injection ,which is more convenient and comfortable with little suffering .