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本文对合成的短效麻醉性镇痛药盐酸四唑芬太尼的化学、药理学、药动学、临床应用、副作用、剂量与用药进行了评价。阿芬太尼是一种叔胺化合物,电离常数6.5在生理pH值约有10％电高。相比于芬太尼,阿芬太尼的效力取决于特定的临床状况和预期的临床目的;本品发生作用较快,作用持续时间是芬太尼的三分之一,药效是四分之一至十分之一,其脂溶性较小,蛋白结合力较大,而且在生理pH值未电离部份多。按体重给药,本品药效约为新芬太尼
In this paper, the chemical, pharmacology, pharmacokinetics, clinical application, side effects, dosage and medication of the synthesized short-acting narcotic analgesic tetrazole fentanyl hydrochloride were evaluated. Alfentanil is a tertiary amine compound with an ionization constant of 6.5 at physiological pH of about 10%. Compared to fentanyl, the effectiveness of alfentanil depends on the specific clinical condition and the intended clinical purpose; this product has a rapid onset of action lasting one-third as much as fentanyl with a potency of four One to one-tenth of its fat-soluble smaller, larger protein binding, but also in the physiological pH value is not ionized. According to body weight, the drug efficacy of about new fentanyl