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目的探讨甲状腺副神经节瘤的临床病理特征及鉴别诊断。方法收集1例甲状腺原发性副神经节瘤的临床资料,观察组织病理学形态、免疫组化染色及特殊染色,并复习相关文献。结果患者女性,36岁。因颈部肿物入院。肿块大体为包膜完整的实性结节。镜下肿瘤由2种类型细胞构成,即多边形主细胞和位于主细胞周边的梭形支持细胞。肿瘤细胞排列成特征性的巢状或球状结构,之间为纤维血管性间质。免疫组化:主细胞CgA、Syn、NSE和蛋白基因产物9.5(PGP9.5)(+),AE1/AE3和EMA(-);支持细胞S-100(+)。特殊染色:刚果红染色(-)。结论甲状腺原发性副神经节瘤是一种罕见的肿瘤,确诊需要依靠病理检查及免疫组化标记,需与甲状腺其他实性肿瘤鉴别。
Objective To investigate the clinicopathological features and differential diagnosis of paraganglioma thyroid. Methods One case of primary paraganglioma of the thyroid gland was collected. The histopathological features, immunohistochemical staining and special staining were observed. The related literatures were reviewed. Results Patients Female, 36 years old. Due to neck mass admission. Mass generally complete solid nodules. Microscopic tumors consist of two types of cells, namely, the main cells of the polygons and the spindle-shaped supporting cells located around the main cells. Tumor cells arranged in a characteristic nested or spherical structure, between the fibrovascular stromal. Immunohistochemistry: Main cell CgA, Syn, NSE and protein gene products 9.5 (PGP9.5) (+), AE1 / AE3 and EMA (-); supporting cells S-100 (+). Special staining: Congo red staining (-). Conclusions The primary paraganglioma of the thyroid gland is a rare tumor which needs to be relied on pathological examination and immunohistochemistry to distinguish it from other solid tumors of the thyroid.