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目前已经发现100种以上药物可以引起肺部损伤,大部分的药物性肺损伤都会伴有咳嗽的发生。1药源性咳嗽的发病机制:引起药源性咳嗽的可能机制主要包括以下3个方面:(1)药物在肺组织的高浓度摄取和活性代谢产物在肺部聚积导致的肺局部毒性反应;(2)药物在肺部的急、慢性过敏反应;(3)药物引起炎性介质在肺部蓄积导
It has been found that more than 100 kinds of drugs can cause lung damage, most of the drug-induced lung injury will be accompanied by the occurrence of cough. 1 drug-induced cough pathogenesis: the possible mechanism of drug-induced cough mainly includes the following three aspects: (1) high concentrations of drugs in the lung tissue uptake and active metabolites in the lungs caused by accumulation of lung local toxicity; (2) drugs in the lungs of acute and chronic allergic reactions; (3) drugs cause the accumulation of inflammatory mediators in the lung