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实验表明细辛可使狗左室泵功能和心肌收缩性能明显改善。在心肺制备狗,主要表现为LVSP↑,LVEDP↓,MAP↑,CO↑,HR↑,SV↓,dp/dt_(max)↑,-dp/dt_(max)↑,t—dp/dt_(max)↓,V_(px)↑,V_(ce-cpip)↑,V_(max)↑;在麻醉开胸狗,除MAP降低和SV增加外,对其它指标的作用方向与心肺制备实验结果基本一致;两个实验中测取的Lissajous图形的正向前降支均向右上方移位。从而排除了前、后负荷的影响,说明泵功能的改善似由于细辛增强心肌收缩性能所致。通过细辛与去甲乌药硷、异丙肾上腺素的比较研究,提示三者的作用基本相似,唯SV显示不同的结果。细辛使SV增加,去甲乌药硷、异丙肾上腺素却使SV减少,这可能与细辛增加HR的比率较二者为低密切相关。肾上腺素能β受体阻滞后,细辛增加CO的作用仍然存在,值得进一步研究。
Experiments show that asarum can make the dog left ventricular pump function and myocardial contractility significantly improved. In heart and lung preparation of dogs, LVSP ↑, LVEDP ↓, MAP ↑, CO ↑, HR ↑, SV ↓, dp / dt max ↑, -dp / dt max ↑, tdp / dt max max ), V_ (px) ↑, V_ (ce-cpip) ↑, V_ (max) ↑. In anesthetized open-chest dogs, except for the decrease of MAP and the increase of SV, the directions of other indexes were basically consistent with the results of cardiopulmonary preparation ; Both anterior descending branches of the Lissajous pattern measured in both experiments shifted to the upper right. Thus ruled out the impact of the front and rear load, indicating that the improvement of pump function seems to be due to Asarum enhanced myocardial contractility. Through the comparison of asarum and noradrenaline and isoprenaline, it is suggested that the effects of them are similar, but only SV shows different results. Asarum SV increased, to aesculin, isoproterenol but to reduce the SV, which may be asarum increased HR ratio than the two are closely related. Adrenergic β-blocker, asarum increased the role of CO still exists, it is worth further study.