为观察铝冶炼厂附近老年人痴呆的的发生率是否增加,调查了168名居住在铝冶炼厂附近的65岁以上的老年人及119名居住在相对无空气污染地区的对照组人群。结果表明,铝冶炼厂附近居民中有25例痴呆(14.9%),对照人群中20例痴呆(16.7%),两组人群痴呆的发生无显著性差异。测定了43名铝冶炼厂附近居民及38名对照人群的血浆铝含量及红细胞(RBC)铝浓度。结果表明,铝炼厂附近人群中血浆铝为4.78±2.38μg/L,显著高于对照人群3.33±1.88μg/L(P<0.01),RBC铝含量为7.71±3.66μg/L,也显著高于对照人群(5.71±3.21μg/L)(P<0.01)。结果还表明铝炼厂附近人群中RBC镉与铝的含量呈显著正相关(r=0.65,P<0.01)。铝与硒、锌呈负相关(r=-0.54,P<0.001;r=-0.52,P<0.01),表明铝冶炼厂附近居民体内铝过剩时,硒和锌的含量下降。铝冶炼厂附近居民体内铝与血浆磷脂脂肪酸呈负相关r=-0.35,P<0.05)。RBC镉与胆甾基油酸酯有明显的负相关(r= To see if there was an increase in the incidence of dementia among the elderly in the vicinity of the aluminum smelter, 168 elderly people aged over 65 living in the vicinity of the aluminum smelter and 119 control subjects living in relatively air-polluted areas were investigated. The results showed that there were 25 cases of dementia (14.9%) among residents near the aluminum smelter and 20 cases of dementia (16.7%) in the control group. There was no significant difference in dementia between the two groups. Plasma aluminum levels and RBC aluminum concentrations were determined for 43 residents near the aluminum smelter and 38 control subjects. The results showed that the plasma aluminum in the population near the aluminum refinery was 4.78 ± 2.38μg / L, which was significantly higher than that of the control population (3.33 ± 1.88μg / L, P <0.01), and the RBC aluminum content was 7.71 ± 3.66μg / L In the control group (5.71 ± 3.21μg / L) (P <0.01). The results also showed a significant positive correlation (r = 0.65, P <0.01) between cadmium and aluminum content in RBC populations near the aluminum refinery. Aluminum and selenium and zinc showed a negative correlation (r = -0.54, P <0.001; r = -0.52, P <0.01), indicating that the content of selenium and zinc decreased when aluminum was surplus in the residents near the smelter. There was a negative correlation between aluminum and plasma phospholipid fatty acid in residents near the aluminum smelter (r = -0.35, P <0.05). RBC cadmium and cholesteryl oleate have a significant negative correlation (r =