眼部新生血管性疾病常并发于多种眼病，是严重损害人类视力的主要因素之一，尤其是视网膜新生血管性疾病，能使视力在短时间内急剧下降。一直以来，国内外很多学者对新生血管的发生机制和防治方法进行了大量体内外的基础和临床研究。目前认为血管内皮生长因子（ VEGF）拮抗剂类药物能够与VEGF相结合并阻断其活性，从而抑制新生血管的形成。“,”Neovascular diseases of eyeball are always complicated with many ocular diseases,which is one of the major factors injuring human visual acuity,especially the retinal neovascular disease.For a long time,experts in and out of China have carried out a lot of basic and clinical,in vivo and in vitro studies about the mechanisms and treatment of eyeball neovascular diseases.At present,it is generally considered that vas-cular endothelial growth factor(VEGF) antagonist can combine with VEGF,and inhibit the VEGF activity, thus restrain the neovascularization.