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目的:分析硬腭恶性肿瘤的治疗效果及影响预后的因素。方法:对1964-2004年在中山大学肿瘤防治中心住院治疗的243例原发于硬腭的恶性肿瘤患者资料进行回顾性分析。应用Kaplan-Meier法计算累计生存率,各因素间比较用秩和对数(Log-rank)检验,多因素分析采用Cox模型。结果:243例患者总的5和10年生存率分别为45.91%和35.74%。单纯手术治疗103例和手术加放疗65例患者的5年生存率分别为60.07%和53.93%,10年生存率分别为52.80%和44.52%。多因素分析结果表明,手术切缘阳性、年龄≥50岁、颈淋巴结转移及肿瘤复发者预后差(P<0.05)。结论:手术治疗或以手术为主的综合治疗是硬腭恶性肿瘤的首选治疗方法。手术切缘情况、年龄、颈淋巴结转移及复发情况是影响硬腭恶性肿瘤患者预后的独立因素。
Objective: To analyze the therapeutic effects of hard palate malignancy and the factors that influence the prognosis. METHODS: A retrospective analysis of 243 patients with primary malignant tumors of hard palate was performed at the Cancer Center of Sun Yat-sen University from 1964 to 2004. Kaplan-Meier method was used to calculate the cumulative survival rate. Log-rank test was used to compare the factors. Cox model was used for multivariate analysis. Results: The total 5-year and 10-year survival rates of 243 patients were 45.91% and 35.74%, respectively. The 5-year survival rates of 103 patients undergoing surgery alone and 65 patients undergoing surgery plus radiotherapy were 60.07% and 53.93%, respectively, and the 10-year survival rates were 52.80% and 44.52%, respectively. Multivariate analysis showed that the prognosis of patients with positive surgical margins, age≥50 years, cervical lymph node metastasis, and tumor recurrence was poor (P<0.05). Conclusion: Surgical treatment or combined treatment based on surgery is the first choice for treatment of hard palate malignant tumors. Surgical margins, age, cervical lymph node metastasis, and recurrence were independent factors influencing the prognosis of patients with hard palate cancer.