目的：研究尼莫地平对感染性水肿的影响．方法：采用百日咳菌液右侧颈内动脉注射造成兔感染性脑水肿模型．１８只家兔随机分为３组（ｎ＝６）．ＢＥ组：注射百日咳菌液（０６ｍＬ·ｋｇ－１）；ＮＳ组：注射生理盐水作为对照．Ｎｉｍ组：注射菌液后１０ｍｉｎ，静注尼莫地平１０μｇ·ｋｇ－１，再以０７５μｇ·ｋｇ－１·ｍｉｎ－１持续静滴，４ｈ后观察右脑伊文斯蓝蓝染，测定右脑水、钙、钙调素及钠含量．结果：Ｎｉｍ与ＢＥ：水８２２±１０％和８４４±１２（Ｐ＜００１）；钙１０５±１３ｍｍｏｌ／ｋｇ干脑和１７５±１４（Ｐ＜００１）；钙调素１５９±１８μｍｏｌ／ｋｇ湿脑和２４０±３０（Ｐ＜０．０１）；钠１７３±７ｍｍｏｌ／ｋｇ干脑和２７５±３８（Ｐ＜００５）．两组脑蓝染无显著性差异．结论：尼莫地平对感染性脑水肿有良好的治疗作用． Objective: To study the effect of nimodipine on infectious edema. Methods: Infectious cerebral edema model was induced by injection of the right internal carotid artery of pertussis bacilli. Eighteen rabbits were randomly divided into three groups (n = 6). BE group: injection of pertussis bacilli (06mL · kg-1); NS group: saline injection as a control. Nim group: 10 min after injection of nimodipine, nimodipine was injected intravenously at a dose of 10 μg · kg-1 and then kept at 075 μg · kg-1 · min-1 for 4 h, Brain water, calcium, calmodulin and sodium content. Results: Nim and BE: water 822 ± 10% and 844 ± 12 (P <001), calcium 105 ± 13mmol / kg dry brain and 175 ± 1 4 (P <001); calmodulin 159 ± 18μmol / kg wet brain and 240 ± 30 (P <0.01); sodium 173 ± 7mmol / kg dry brain and 275 ± 38 (P <005). There was no significant difference between the two groups in brain blue dye. Conclusion: Nimodipine has a good therapeutic effect on infectious brain edema.