目的 为研究微血管的密度与直肠癌浸润转移的关系,本文应用免疫组化对微血管密度进行检测。方法 病例选自我院1993～1996年间直肠癌手术切除病例110例,应用常规石腊切片,免疫组化染色。微血管密度检测,在10×10倍视野下选择微血管最多的视野3个,每例切片先后两次计数,然后取其平均值,经X~2检验进行资料数据处理。结果 110例直肠腺癌微血管的平均值为63.1/每野100x,其并有肝转移者平均84.6/每10x。结论 血管密度增加与肝转移有关,与其组织学分类分级、淋巴结转移关系不明显,与肿瘤浸润深度有关。 Objective To study the relationship between the density of microvessels and the invasion and metastasis of rectal cancer, the microvessel density was detected by immunohistochemistry. Methods The cases were selected from 110 cases of resected rectal cancer in our hospital from 1993 to 1996. The specimens were paraffin-embedded and immunohistochemically stained. Microvessel density test, in 10 × 10 times the field of vision to select the most micro-vascular 3, each case has two counts, and then take the average, by X ~ 2 test data processing. Results The average of the microvessels in 110 patients with rectal adenocarcinoma was 63.1 per field 100x with an average of 84.6 per 10x liver metastases. Conclusions The increased blood vessel density is related to liver metastasis, but not to the histological classification and lymph node metastasis, which is related to the depth of tumor invasion.