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目的 :探讨 JWA基因表达与不同病期急性非淋巴细胞白血病 ( ANL L )的相关意义。方法 :应用逆转录 -聚合酶链反应( RT- PCR)技术检测 2 4例不同病期的 ANL L 患者骨髓和 (或 )外周血中 JWA基因的表达。结果 :JWA基因表达在初发 ANL L为13 /13 ( 10 0 %阳性 ) ,完全缓解时为 1/4,复发患者为 3 /4,由骨髓增生异常综合征 ( MDS)转化而来为 1/3。结论 :JWA可能参与原发 ANL L 的某个发病过程 ,其与白血病的发生、发展以及预后的关系有待进一步研究
Objective: To investigate the relationship between JWA gene expression and acute non-lymphocytic leukemia (ANL L) at different stages of disease. Methods: The expression of JWA gene in bone marrow and / or peripheral blood of 24 patients with ANL L at different stages was detected by reverse transcription-polymerase chain reaction (RT-PCR). Results: The expression of JWA gene was 13/13 (100% positive) in primary ANL, 1/4 in complete remission and 3/4 in relapsed patients, which was transformed from MDS to 1 / 3. Conclusion: JWA may participate in the pathogenesis of primary ANL L and its relationship with the occurrence, development and prognosis of leukemia remains to be further studied