论文部分内容阅读
目的:探讨10种肿瘤标志物对肺癌诊断临床价值。方法:临床确诊的肺癌患者40例为肺癌组,非肿瘤患者30例为对照组。用化学发光法检测癌胚抗原(CEA)、糖类抗原199(CA-199)、糖类抗原125(CA-125)、糖类抗原153(CA-153)等10种血清肿瘤标志物,临床评价血清肿瘤标志物不同组合的灵敏度、特异性、准确度、阳性预测值、阴性预测值。结果:肺癌组血清CEA、CA-199、CA-125和CA-153检测水平值均明显高于对照组(P<0.01)。CEA有高灵敏度和准确度(95%和87.14%),CEA和CA-199有高特异性(76.67%)。肿瘤标志物两两联合或三项联合,对肺癌诊断的灵敏度、准确度、特异性均有明显提高(P<0.001)。结论:CEA等肿瘤标志物检测水平值对肺癌的诊断有临床应用价值,联合检测可适度提高诊断的灵敏度和准确度。
Objective: To investigate the clinical value of 10 tumor markers in the diagnosis of lung cancer. Methods: Forty lung cancer patients diagnosed as lung cancer group and 30 non-tumor patients as control group. Chemiluminescence was used to detect 10 serum tumor markers such as carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA-199), carbohydrate antigen 125 (CA-125) and carbohydrate antigen 153 The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of different combinations of serum tumor markers were evaluated. Results: The levels of serum CEA, CA-199, CA-125 and CA-153 in lung cancer group were significantly higher than those in control group (P <0.01). CEA has high sensitivity and accuracy (95% and 87.14%), CEA and CA-199 have high specificity (76.67%). Twenty-two or three tumor markers combined, the diagnosis of lung cancer sensitivity, accuracy and specificity were significantly improved (P <0.001). Conclusion: The detection of tumor markers such as CEA has clinical value in the diagnosis of lung cancer. Combined detection may improve the sensitivity and accuracy of diagnosis.