肾损害是多发性骨髓瘤(MM)最常见的严重并发症之一〔1〕。10%～40%MM确诊时已出现肾功能损害,整个病程中25%～50%的MM患者会出现程度不同的肾功能异常〔2-3〕。美国和欧洲对过去数年终末期肾病的统计数据显示,由MM引起 Renal damage is one of the most common and serious complications of multiple myeloma (MM) [1]. 10% ~ 40% MM has been diagnosed with renal damage, the entire course of 25% to 50% of MM patients will appear different degrees of renal dysfunction [2-3]. Statistics from the United States and Europe over the last few years of end-stage renal disease show that it is caused by MM