在嘉靖三十三年(1554年)澳门开埠之前,葡萄牙商人、东南亚海商等已经在广东沿海频繁活动。澳门开埠早期的葡人居留地是在澳门半岛西北部的沙梨头一带,葡萄牙人之所以开埠于沙梨头一带,不仅是因为当地拥有优良的停泊处,位置适中,内外交通便利,更为重要的是白鸽巢山的军事防卫作用和供给饮用水源的便利条件。葡萄牙人在澳门开埠以后,其在澳门的势力与日俱增,除从事正常贸易外,也时常对广东尤其是广州府沿海地带进行武力骚扰,广东中路的海防形势发生了重大变化,广东海防的重心相应地从东路转向了中路。 Before the opening of Macao in the 34th year of Jiajing (1554), Portuguese businessmen, Southeast Asian maritime merchants, etc. had been active in the coast of Guangdong. The early Portuguese residence in the port of Macao opened in the area of ​​Sa Rau Tau in the northwestern part of the Macau Peninsula. The reason why the Portuguese opened their ports in Sa Rau Tau was not only because they have excellent berths but also have a moderate location with convenient transportation both inside and outside. What matters is the military defense of the dove of Pigeon and the convenience of supplying drinking water sources. After Macao opened its doors in Macao, its forces in Macao are increasing day by day. In addition to normal trade, the Portuguese often harass armed forces along the coastal areas of Guangdong, especially Guangzhou, and the situation of coastal defense in Guangdong has undergone major changes. The focus of Guangdong’s coastal defense Turn from East Road to Middle Road.