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自冠心病监护病房(CCU)引用于临床以来,急性心肌梗塞(下称AMI)死于心律失常者已显著减少,但死于心力衰竭及心原性休克者仍多。后两者主要与心肌梗塞范围及其所带来的血液动力学障碍有关。大部分AMI患者是由于动脉粥样硬化的内膜破裂、出血,导致血栓形成,或可同时伴有冠状动脉痉挛。冠状动脉发生阻塞后,除造成心肌坏死之外,梗塞区的周围及其远端即陷于缺血状态。如在心肌梗塞早期将冠状动脉内血栓溶解,虽不能使梗塞的心肌复元,但可使尚未坏死或缺血区域免于坏死而可缩小梗塞范围。1979年Rentrop以链激酶作冠状动脉内直接注入,使血栓溶解,管腔再通,称作经皮经腔冠状动
Since the introduction of CCU in the clinic, acute myocardial infarction (hereinafter referred to as AMI) has been significantly reduced due to arrhythmia, but died of heart failure and cardiogenic shock were still more. The latter two are mainly related to the extent of myocardial infarction and the hemodynamic disorders it brings. Most AMI patients are due to rupture of atherosclerotic endometrium, bleeding, leading to thrombosis, or may be accompanied by coronary spasm. Coronary occlusion, in addition to causing myocardial necrosis, around the infarct area and its distal is in an ischemic state. As in the early myocardial infarction coronary thrombolysis, although not myocardial infarction complex, but can not necrosis or ischemic area may be necrosis and can reduce the infarct size. Rentrop in 1979 streptokinase for coronary artery direct injection, thrombolysis, lumen recanalization, known as percutaneous transluminal coronary