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目的研究DNA修复基因XRCC3 Thr 241 Met(rs861539)遗传变异与喉癌风险的关系。方法采用Multiplex SNaPshot技术(多重单碱基延伸反应技术)对60例喉癌患者和120名正常人进行基因分型,采用多因素Logistic回归模型计算各基因型携带者喉癌的发病风险,以及与吸烟交互对喉癌发病风险的影响。结果XRCC3 24l Met等位基因增加了喉癌发病风险,与XRCC3 241Thr/Thr基因型携带者相比,至少携带一个241 Met等位基因的个体罹患喉癌的OR为4.27,95%CI为1.49~12.18。结论XRCC3Thr 241 Met单核苷酸多态是喉癌的遗传易感因素。
Objective To investigate the relationship between the genetic variation of DNA repair gene XRCC3 Thr 241 Met (rs861539) and the risk of laryngeal cancer. Methods Sixty patients with laryngeal cancer and 120 normal subjects were genotyped by multiplex SNaPshot technique (multiplex single base extension reaction). Multivariate Logistic regression model was used to calculate the risk of laryngeal cancer in each genotype. Effect of smoking interaction on the risk of laryngeal cancer. Results XRCC3 24l Met allele increased the risk of laryngeal cancer. Compared with XRCC3 241Thr / Thr genotype, the OR of at least one 241 Met allele in patients with laryngeal carcinoma was 4.27 and the 95% CI was 1.49 ~ 12.18. Conclusion XRCC3Thr 241 Met SNP is a predisposing factor for laryngeal cancer.