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目的探讨石英粉尘接尘人员外周静脉血红细胞膜丙二醛(MDA)负荷分类情况的主要影响因素。方法运用整群抽样研究方法,抽取陶瓷企业石英粉尘健康接尘人员179名,采集外周静脉血2 m l,肝素钠抗凝,以硫代巴比妥法检测红细胞膜MDA负荷,计算MDA的平均负荷作为标准参考值;利用调查表对接尘人员的10个可能影响因素进行调查;同时,对厂内各工序点的生产环境噪声及粉尘浓度进行监测;以接尘人员MDA负荷分类(设大于或小于标准参考值的二分变量)为应变量,以被调查的10个可能影响因素为自变量,运用成组资料的非条件Logistic回归分析模型拟合回归曲线,探寻主要影响因素。结果工龄、粉尘浓度、是否经常佩戴防护口罩、饮茶情况及吸烟等5个因素,最终进入回归方程(α=0.05)。结论进入回归方程的5个因素为影响接尘工人红细胞膜MDA负荷的最主要因素。
Objective To investigate the main influencing factors of malondialdehyde (MDA) load classification in peripheral venous red blood cells of quartz dust dust collector. Methods A cluster sampling method was used to collect 179 quartz dust collectors from ceramic enterprises. Peripheral venous blood samples were collected for 2 ml. Heparin sodium was anticoagulated. The MDA load of erythrocyte membrane was measured by thiobarbiturine method. The average load of MDA As a standard reference value; the use of a questionnaire to survey the dust potential of 10 possible factors to investigate; the same time, the plant each process point of production environment noise and dust concentration monitoring; to dust personnel MDA load classification (set greater than or less than Standard dichotomous reference value) as the dependent variable, and the 10 potential influential factors to be surveyed as independent variables. The non-conditional logistic regression model of the group data was used to fit the regression curve to explore the main influencing factors. Results The length of service, dust concentration, whether to wear protective masks often, drinking tea and smoking were the five factors that finally entered the regression equation (α = 0.05). Conclusion The five factors that entered the regression equation are the most important factors that affect the MDA load of erythrocyte membrane in workers exposed to dust.