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目的：研究兔抗人白蛋白免疫羧化胶乳对大肠肿瘤普查的临床意义。方法：应用致敏羧化胶乳的方法制备了兔抗人白蛋白免疫羧化胶乳试剂。用反向胶乳凝集试验检测经结肠镜检出和病理证实的２６９例大肠肿瘤和结肠炎患者以及１６１例正常人的粪微量白蛋白。结果：该试剂灵敏性高（３１２５ｎｇ／ｍｌ）；检测牛、马、羊、豚鼠等动物血清呈阴性反应；用多批次免疫羧化胶乳平行检测并在有效期内重复检测已知阳性标本，其重复性良好。结论：该试剂对大肠癌的诊断敏感性７６８％，特异性８００％，准确性７７０％。
Objective: To study the clinical significance of rabbit anti-human albumin immunized carboxylated latex in the general survey of colorectal neoplasms. Methods: Rabbit anti-human albumin immunized carboxylated latex reagent was prepared by means of sensitized carboxylated latex. A retrograde latex agglutination test was used to detect fecal microalbumin in 269 colonic and colitis patients and 161 normal controls confirmed by colonoscopy and pathology. RESULTS: The reagent was highly sensitive (3125 ng/ml); negative serum was detected in animals such as cows, horses, sheep, guinea pigs, etc.; multiple batches of immunized carboxylated latex were tested in parallel and the positive samples were repeatedly tested during the validity period. The repeatability is good. Conclusion: The diagnostic sensitivity for colorectal cancer is 76.8%, specificity is 80.0%, and accuracy is 77.0%.