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目的探讨甲状腺功能亢进患者经抗甲状腺药物治疗前后脂联素的变化及相关因素。方法 97例甲状腺功能亢进患者经6个月抗甲状腺药物治疗后,观察甲状腺功能恢复正常的78例患者治疗前后空腹血糖、胰岛素、血脂、脂联素水平和体重指数;对治疗前后血清脂联素与BMI、甲状腺激素、血脂、胰岛素抵抗指数等变量进行相关分析。结果治疗6个月后FT3、FT4、TSH恢复正常,BMI升高,HOMA-IR下降,血清脂联素水平下降。治疗前,血清脂联素与BMI、HOMA-IR呈负相关,与FT4、FT3呈正相关;治疗后,血清脂联素仍然与FT4、FT3呈正相关,与BMI呈负相关。控制BMI、性别、年龄等因素后的偏相关分析表明血清脂联素仍然与FT4呈正相关。结论甲亢患者血清脂联素升高,甲状腺功能正常后恢复正常,甲状腺激素水平影响脂联素水平。
Objective To investigate the changes and related factors of adiponectin in patients with hyperthyroidism before and after anti-thyroid drug treatment. Methods 97 patients with hyperthyroidism were treated with antithyroid drugs for 6 months. The fasting blood glucose, insulin, blood lipid, adiponectin levels and body mass index (BMI) were measured in 78 patients with normal thyroid function before and after treatment. And BMI, thyroid hormone, blood lipids, insulin resistance index and other variables were analyzed. Results FT3, FT4, TSH returned to normal after 6 months of treatment, BMI increased, HOMA-IR decreased, serum adiponectin level decreased. Before treatment, serum adiponectin was negatively correlated with BMI and HOMA-IR, and positively correlated with FT4 and FT3. After treatment, serum adiponectin was still positively correlated with FT4 and FT3 and negatively correlated with BMI. Partial correlation analysis after controlling for BMI, gender, age and other factors showed that serum adiponectin was still positively correlated with FT4. Conclusions Serum levels of adiponectin are elevated in patients with hyperthyroidism and return to normal after thyroid function is normal. The level of thyroid hormone affects the level of adiponectin.