结合珠蛋白(Haptoglobin,Hp)是一种急性期血浆蛋白,可保护组织免受氧化损伤。它存在2个变异等位基因(hp1/hp2),产生具有不同生化特性和不同功能的3种蛋白质异构体。先前研究发现,hp2变异与颈动脉狭窄患者的脑卒中相关,在一般人群队列中也与缺血性心血管事件的风险相关。该研究旨在验证Hp基因型与脑卒中患者中一般心血管事件风险相关 Haptoglobin (Hp) is an acute phase plasma protein that protects tissues from oxidative damage. It has two variant alleles (hp1 / hp2), producing three protein isoforms with different biochemical characteristics and different functions. Previous studies have found that the hp2 mutation is associated with stroke in patients with carotid artery stenosis and is also associated with an increased risk of ischemic cardiovascular events in the general cohort. The study was designed to demonstrate that Hp genotypes are associated with a general cardiovascular risk in stroke patients