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目的检测重度子痫前期孕妇胎盘组织中儿茶酚-O-甲基转移酶(COMT)的表达量,探讨其在重度子痫前期发病机制中的作用。方法选择重度子痫前期孕妇15例(病例组),正常孕妇15例(对照组),采用蛋白印迹方法 (western blotting)检测两组胎盘组织中COMT蛋白的表达量。结果病例组和对照组胎盘组织中COMT蛋白表达量比较,差异有统计学意义(P<0.05)。结论重度子痫前期孕妇胎盘组织中COMT蛋白的表达量低于正常孕妇,提示COMT蛋白可能参与了重度子痫前期的发病。
Objective To investigate the expression of catechol-O-methyltransferase (COMT) in placenta of severe preeclampsia and its role in the pathogenesis of severe preeclampsia. Methods 15 pregnant women with severe preeclampsia (case group) and 15 normal pregnant women (control group) were enrolled in this study. The expression of COMT protein in placenta was detected by western blotting. Results There was significant difference in the expression of COMT protein in placenta between case group and control group (P <0.05). Conclusion The expression of COMT protein in placental tissue of pregnant women with severe preeclampsia is lower than that of normal pregnant women, suggesting that COMT protein may be involved in the pathogenesis of severe preeclampsia.