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目的研究冠心病支架植入术前、术后不同时间相sCD40L水平变化,以探讨sCD40L与再狭窄的可能关系。方法选择接受普通支架置入术的冠心病患者41例(研究组),健康正常对照组16例。分别于术前、术后1,5,15,180d取外周静脉血测定血清sCD40L。所有患者随访6个月。结果冠心病患者术前血清sCD40L为(6.54±1.55)ng/ml,明显高于对照组的(2.11±0.68)ng/ml(P<0.05)。支架内再狭窄率24.4%(10/41)。再狭窄患者支架术前sCD40L水平为(7.34±1.25)ng/ml,明显高于无再狭窄患者的(4.36±0.98)ng/ml;术后血清sCD40L水亦显著高于无再狭窄患者(P均<0.01);再狭窄患者支架术后高水平sCD40L持续至术后6月,而无再狭窄患者术后5d则恢复至正常。结论再狭窄患者支架术前、术后血清sCD40L水平增加提示sCD40L可能与支架内再狭窄有关。
Objective To study the changes of sCD40L level before and after coronary stenting in order to investigate the possible relationship between sCD40L and restenosis. Methods 41 cases of coronary heart disease (study group) and 16 healthy control group were enrolled in the study. Peripheral venous blood samples were collected before and after operation for 1, 5, 15 and 180 days respectively. Serum sCD40L was measured. All patients were followed up for 6 months. Results The preoperative serum sCD40L was (6.54 ± 1.55) ng / ml in patients with coronary heart disease, which was significantly higher than that of the control group (2.11 ± 0.68) ng / ml (P <0.05). In-stent restenosis rate was 24.4% (10/41). The preoperative sCD40L level in patients with restenosis was (7.34 ± 1.25) ng / ml, which was significantly higher than that in patients without restenosis (4.36 ± 0.98) ng / ml. The serum sCD40L level in patients with restenosis was also significantly higher than that in patients without restenosis All <0.01). The high level of sCD40L in patients with restenosis was continued to 6 months after operation, while those without restenosis returned to normal 5 days after operation. Conclusion The increase of serum sCD40L levels in patients with restenosis before and after stenting suggests that sCD40L may be related to in-stent restenosis.