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成人呼吸窘迫综合征(ARDS)为临床各科所常见,且病死率很高。关于ARDS的发病机理目前还不分清楚,本实验旨在观察神经抑制性药物苯巴比妥钠对实验性油酸型呼吸窘迫综合征的预防作用。实验应用Wistar雄性大鼠40只,分为3组。A组:生理盐水对照组(n=10),于尾静脉注入生理盐水0.1ml/kg;B组:非预防组(n=15),于尾静脉注入油酸0.1ml/kg;C组:苯巴比妥钠预防组,在尾静脉注入油酸0.1ml/kg前15min,向腹腔内注入苯巴比妥钠40mg/kg。注射油酸后6h处死全部大鼠,立即取出肺组织观察肉眼改变,测肺湿重,求肺系数,并作光镜及电镜组织学观察。结果显示:苯巴比
Adult respiratory distress syndrome (ARDS) is common in all clinical departments and has a high case fatality rate. About the pathogenesis of ARDS is not yet clear, the purpose of this experiment is to observe the neuroprotective drug phenobarbital sodium in experimental oleic-type respiratory distress syndrome prevention. Forty Wistar male rats were divided into three groups. Group A: normal saline control group (n = 10), saline 0.1ml / kg was injected into caudal vein; group B: non-prophylaxis group (n = 15) Phenobarbital sodium prophylaxis group, phenobarbital sodium 40mg / kg was intraperitoneally injected 15 min before the tail vein injection of oleic acid 0.1ml / kg. Six hours after injection of oleic acid, all the rats were sacrificed, the lungs were immediately removed and the macroscopic changes were observed. The lung wet weights and lung coefficients were measured and observed for light and electron microscopy. The results show: phenobarbital