论文部分内容阅读
目的：探讨新生儿缺氧缺血性脑病（ＨＩＥ）时血浆内皮素、心钠素、钙、钠的变化及临床意义。方法：应用放射免疫法测定３２例ＨＩＥ患儿内皮素、心钠素及钙、钠的浓度水平，并与正常新生儿组进行对照。结果：急性期ＨＩＥ患儿血浆内皮素、心钠素含量明显高于对照组，而血清钙、钠水平则低于对照组；随病情恢复内皮素及心钠素逐渐下降伴血钙、钠浓度上升。结论：内皮素与心钠素参与ＨＩＥ的病理生理过程，测定内皮素及心钠素有助于早期ＨＩＥ的诊断。
Objective: To investigate the changes of plasma endothelin, atrial natriuretic peptide, calcium and sodium in neonates with hypoxic-ischemic encephalopathy (HIE) and its clinical significance. Methods: The levels of endothelin, atrial natriuretic peptide, calcium and sodium in 32 HIE children were determined by radioimmunoassay and compared with normal neonates. Results: The levels of plasma endothelin and atrial natriuretic peptide in children with acute HIE were significantly higher than those in the control group, while the levels of serum calcium and sodium were lower than those in the control group. With the recovery of endothelin and atrial natriuretic peptide, rise. Conclusion: Endothelin and atrial natriuretic peptide are involved in the pathophysiological process of HIE, and the determination of endothelin and atrial natriuretic peptide are helpful for the diagnosis of early HIE.