自1899年发现阿司匹林后,名副其实成为临床使用已有百余年的解热、消炎、镇痛和治疗风湿的标准药物。被认为是极安全、较理想的对症治疗药物,药效迅速,价格低廉。特别是20世纪90年代以来,国内外报道阿司匹林用来治疗动脉硬化、癌症、老年痴呆后,人们对其有了重新的认识,在临床治疗上的新用途引起了极大兴趣和重视。因此,阐明其药源疾病作用机制,发挥老药新用途,具有十分重要的临床意义。1阿司匹林药源疾病的作用机制1.1阿司匹林引起的胃肠疾病药物口服后,经胃肠吸收而作用于全身,或留于胃肠道作用于胃肠局部。临床上防止阿司匹林对胃肠道刺激的措施很多,如同时服用维生素K;与抗酸药胃舒平同服;应用肠溶片。阿司匹林抑制了环氧酶,使花生四烯酸不能转变为前列腺素,前列腺素是致炎物质,因而 Since the discovery of aspirin in 1899, it has become a standard medicine for antipyretic, anti-inflammatory, analgesic and rheumatism that has been clinically used for over 100 years. Is considered to be extremely safe, the ideal symptomatic treatment of drugs, rapid efficacy, low prices. Especially since the 1990s, aspirin has been widely used in the treatment of atherosclerosis, cancer and dementia in the world, and people have re-cognition of it. New uses in clinical treatment have aroused great interest and attention. Therefore, elucidating the mechanism of action of drug-source diseases and giving play to the new uses of old drugs have very important clinical significance. 1 Aspirin drug-induced disease mechanism 1.1 Aspirin-induced gastrointestinal diseases After oral administration of drugs, through the gastrointestinal absorption and role in the body, or left in the gastrointestinal tract role in gastrointestinal local. Clinical measures to prevent aspirin on the gastrointestinal tract are many, such as taking vitamin K at the same time; and antacids with stomach Shu-ping with the service; the application of enteric-coated tablets. Aspirin inhibits cyclooxygenase, arachidonic acid can not be converted to prostaglandins, prostaglandins are pro-inflammatory substances, and thus