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目的:分析胺碘酮治疗老年性室性心律失常的疗效及其安全性。方法:将我院120例年龄≥65岁室性心律失常患者随机分为A、B、C3组,每组4例,其中A组给予普鲁帕酮治疗,B、C组分别给予不同剂量的胺碘酮,观察疗效及其不良反应。结果:A、B、C三组的总有效率分别为67.5%、85.0%和87.5%,A组与B、C组之间均具有显著性差异(P<0.05),B、C组之间无显著性差异(P>0.05)。结论:胺碘酮治疗老年性室性心律失常疗效显著,安全性较好;并且小剂量给药的不良反应发生率更低,值得临床采用。
Objective: To analyze the efficacy and safety of amiodarone in the treatment of senile ventricular arrhythmia. Methods: A total of 120 patients with ventricular arrhythmias aged 65 years or older in our hospital were randomly divided into A, B and C3 groups, 4 in each. Serums of group A were treated with propafenone, while group B and C were given different doses of Amiodarone, to observe the efficacy and adverse reactions. Results: The total effective rates in groups A, B and C were 67.5%, 85.0% and 87.5%, respectively. There was significant difference between group A and group B and group C (P <0.05) No significant difference (P> 0.05). Conclusion: Amiodarone is effective and safe in the treatment of senile ventricular arrhythmia. And the incidence of adverse reactions in low dose administration is lower, which is worthy of clinical application.