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目的多西紫杉醇联合希罗达是近年来治疗转移性乳腺癌的一个新方案,本文探讨多西紫杉醇联合希罗达(DX)治疗晚期乳腺癌的近期疗效及毒副反应情况。方法希罗达2500 mg/(m2.d),第1～14天分2次饭后30 min口服;多西紫杉醇75 ml/m2,静脉滴注第1天,21 d为一个周期。结果33例患者使用DX方案化疗共112周期,中位周期数为3.2个。总有效率(RR)为45%(15/33),完全缓解(CR)4例(12%)。主要毒副反应为乏力、骨髓抑制、胃肠道反应、手足综合征、口腔黏膜炎等。结论多西紫杉醇与希罗达联合治疗晚期转移性乳腺癌,有效率高,疗效肯定,毒副反应轻,值得推广应用。
AIM: Docetaxel combined with Xeloda is a new regimen for the treatment of metastatic breast cancer in recent years. This article discusses the short-term efficacy and side effects of docetaxel combined with Xeloda (DX) in the treatment of advanced breast cancer. Methods Xeloda 2500 mg / (m2.d), 1 to 14 days 2 times 30 min after meal oral; docetaxel 75 ml / m2, on the first day of intravenous infusion, 21 d for a cycle. Results A total of 112 cycles of DX regimen were used in 33 patients with a median of 3.2 cycles. The total effective rate (RR) was 45% (15/33) and complete remission (CR) was 4 (12%). The main side effects are fatigue, myelosuppression, gastrointestinal reactions, hand-foot syndrome, oral mucositis and so on. Conclusion Docetaxel combined with Xeloda in the treatment of advanced metastatic breast cancer has high efficiency, positive curative effect and light toxicity. It is worth popularizing and applying.