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目的探讨人8-羟基鸟嘌呤糖苷酶1(rs 1052133)的基因多态性(h OGG1 Ser326Cys)与高频听力损失易感性的关系。方法采用病例-对照的研究方法,根据《职业性噪声聋诊断标准》(GBZ49—2007),病例组为电测听双耳高频平均听阈≥40 d B的工人,对照组为年龄和性别与病例匹配且电测听双耳高频平均听阈<40 d B的同岗位轮班工人,基因型的测定采用Taqman探针法。结果通过分析发现h OGG1 Cys/Cys基因型可能是高频听力损失的危险因素(调整OR=2.82,95%CI=1.38~5.77),分层分析发现h OGG1 Cys/Cys基因型与噪声作业工龄(<15年)、噪声暴露水平[<85 d B(A)]和吸烟等危险因素结合后,危险性可能增加(OR值变大)。结论 h OGG1 Cys/Cys基因型可能是汉族人群高频听力损失的危险因素之一。
Objective To investigate the relationship between the gene polymorphism of hGG1 Ser326Cys and the susceptibility to high frequency hearing loss in human 8-oxoguaninease 1 (rs 1052133). Methods According to the diagnostic criteria of occupational noise and deafness (GBZ49-2007), case-control study was conducted. The patients in the case group were workers whose hearing thresholds were ≥40 d B for both ears. The control group was age and gender Case Matching and Electro-audiometry Both sides of high-frequency audible hearing threshold <40 d B shift workers on the same job, the determination of genotype using Taqman probe method. Results H OGG1 Cys / Cys genotypes were found to be risk factors for high-frequency hearing loss (adjusted OR = 2.82, 95% CI = 1.38-5.77). Stratified analysis revealed that h OGG1 Cys / Cys genotype and noise age (<15 years), noise exposure level [<85 d B (A)], and risk factors such as smoking, the risk may increase (OR value increases). Conclusion h OGG1 Cys / Cys genotypes may be one of the risk factors of high frequency hearing loss in Han population.