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目的探讨分析糖化血红蛋白和N末端脑钠肽原与急性冠脉综合征心功能的相关性。方法选择70例急性冠脉综合征(ACS)患者作为A组,其中40例合并糖尿病的患者为A1组,30例无糖尿病的患者为A2组;同期健康体检者26名作为B组,对所有入选者进行血清学检查,比较分析A、B两组入选者糖化血红蛋白(HbA1c)和N末端脑钠肽原(NT-proBNP)的水平。结果 A1组的HbA1c水平明显较A2、B组高,差异有统计学意义(P<0.05);A2组与B组间比较差异无统计学意义(P>0.05)。A1、A2组NT-proBNP水平明显高于B组,A2组明显高于A1组,差异均具有统计学意义(P<0.05)。ACS患者中,HbAlc与NT-proBNP的水平会随着病情的加重而显著增加,差异有统计学意义(P<0.05)。HbA1c与NT-proBNP的水平呈正比。结论 ACS患者的HbA1c与NT-proBNP的水平显著升高,对HbA1c与NT-proBNP的水平进行血清学联合检测,对ACS的临床诊断具有重要意义。
Objective To investigate the relationship between glycated hemoglobin and N-terminal pro-brain natriuretic peptide and the cardiac function of acute coronary syndrome. Methods Seventy patients with acute coronary syndrome (ACS) were enrolled as group A, 40 patients with diabetes mellitus (group A1), 30 patients without diabetes (group A2) and 26 healthy subjects The participants were enrolled for serological examination. The levels of HbA1c and NT-proBNP in group A and B were compared. Results The level of HbA1c in group A1 was significantly higher than that in group A2 and group B (P <0.05). There was no significant difference between group A2 and group B (P> 0.05). The level of NT-proBNP in A1 and A2 groups was significantly higher than that in group B, A2 group was significantly higher than A1 group, the difference was statistically significant (P <0.05). ACS patients, HbAlc and NT-proBNP levels with the severity of the disease increased significantly, the difference was statistically significant (P <0.05). HbA1c is proportional to the level of NT-proBNP. Conclusions The levels of HbA1c and NT-proBNP in patients with ACS are significantly increased. Serological detection of HbA1c and NT-proBNP levels is of great significance in the clinical diagnosis of ACS.