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胃癌是我国较常见的恶性肿瘤,恶性程度高,侵袭力强,生存率低,手术切除(R0切除)被认为是其目前最主要、最有效的治疗方法。但由于肿瘤生物学行为特征,进展期胃癌即便是行根治性切除手术,局部复发率也达50%以上[1],术后5年生存率仅在10%～49%之间[2],单纯手术治疗的效果较差。为了进一步提高进展期胃癌的治疗效果,目前多采用外科手术、化疗、放疗为主的综合治疗模式。已有多项临床研究证实,术前辅助性放化疗可提高根治性切除率,降低复发转移率,延长生存期。
Gastric cancer is one of the most common malignant tumors in our country. It has a high degree of malignancy, strong invasiveness and low survival rate. Surgical resection (R0 resection) is considered as the most important and effective treatment. However, due to the characteristics of tumor biological behavior, advanced gastric cancer, even radical resection, the local recurrence rate of 50% or more [1], postoperative 5-year survival rate was only 10% to 49% [2] Surgical treatment alone is less effective. In order to further improve the therapeutic effect of advanced gastric cancer, the current use of more surgical, chemotherapy, radiotherapy-based comprehensive treatment model. A number of clinical studies have confirmed that preoperative adjuvant radiotherapy and chemotherapy can increase the radical resection rate, reduce the recurrence and metastasis rate, prolong survival.