胰腺纤维化是慢性胰腺炎的主要病理学特征,而活化的胰腺星形细胞(PSC)是胰腺纤维化发生的始动细胞,也是纤维化过程中的主要效应细胞。国内外研究发现多种因素,如细胞因子(常见的有血小板衍化生长因子、转化生长因子β1、白细胞介素10)、激活蛋白、氧应激及细胞内压力等诸多因素,均可通过各自的作用来影响PSC的活性,最终通过丝裂原活化蛋白激酶途径、TGF-β/Smad信号转导蛋白、过氧化物酶体增殖物激活受体γ等细胞内信号调节PSC的活化、增殖及胰腺慢性炎症和纤维化形成过程。 Pancreatic fibrosis is the major pathological feature of chronic pancreatitis. Activated pancreatic astrocytes (PSCs) are the initiating cells of pancreatic fibrosis and also the main effector cells in the process of fibrosis. Domestic and foreign research found that a variety of factors, such as cytokines (common platelet-derived growth factor, transforming growth factor β1, interleukin 10), activin, oxygen stress and intracellular pressure and many other factors, Effect on the activity of PSC, and finally regulate the activation and proliferation of PSC through the mitogen-activated protein kinase pathway, TGF-β / Smad signal transduction protein and peroxisome proliferator-activated receptor γ, Chronic inflammation and fibrosis formation.