母乳低聚糖(HMOS)在母乳中的含量仅次于乳糖和脂肪,其生理功能受到越来越多的重视。在对母乳低聚糖的研究中,关键问题之一是灵敏和可定量的检测方法。由于母乳低聚糖属于复杂的混合物,结构多样,且没有内在的发色团,使得对其进行结构分辨和定量检测都存在不小的难度。本文拟对母乳低聚糖检测方法的研究进展进行综述。 Human milk oligosaccharides (HMOS) in breast milk content in the second only to lactose and fat, its physiological functions are more and more attention. In the study of breast milk oligosaccharides, one of the key issues is sensitive and quantifiable detection methods. Because of the complex mixture of breast milk oligosaccharides, the structure is diverse, and there is no inherent chromophore, making its structural resolution and quantitative detection there is no small difficulty. This article intends to review the progress of detection methods of breast milk oligosaccharides.