肿瘤乏氧细胞的存在是影响肿瘤生物学特性的重要因素之一,它不仅使肿瘤本身更具侵袭性,而且能引起肿瘤细胞对放化疗的抗拒性[1,2]。因此,在对肿瘤进行治疗前,有必要检测其乏氧程度。采用体外无创伤非侵入性方法评估肿瘤的乏氧性具有重要的临床意义,其中乏氧显像剂的测定在临床 The existence of tumor hypoxia cells is one of the important factors affecting the biological characteristics of the tumor, which not only makes the tumor itself more invasive, but also causes tumor cells to resist chemotherapy and radiotherapy [1,2]. Therefore, the tumor before treatment, it is necessary to detect the degree of hypoxia. In vitro noninvasive non-invasive evaluation of tumor hypoxia has important clinical significance, in which the determination of hypoxic imaging agents in clinical