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泰必利(硫必利,Tiaptide)为一种含甲砜基的苯甲酰胺衍生物。已广泛用于治疗神经系统的多种感觉、运动和精神疾病。本文对近年来本品在国内的应用情况作一简略介绍。1 作用机制 ①该药能选择性地作用于中脑边缘系统和纹状体中处于病理状态的多巴胺D_2受体,使之重新恢复与乙酰胆碱能受体系统的平衡,是治疗精神障碍的药理基础。②能提高血浆中β-内啡肽水平,阻滞疼痛冲动经脊髓丘脑束网状结构的传导,对疼痛的治疗效果有关。
Tiapride (Tiaptide) is a methyl sulfone group containing benzamide derivatives. Has been widely used to treat various senses of the nervous system, motor and mental illness. This article in recent years, the application of this product in the country made a brief introduction. 1 mechanism of action ① The drug can selectively act on the midbrain and striatum in the pathological state of the dopamine D_2 receptor, so that the recovery and the balance of acetylcholine receptor system is the pharmacological basis for the treatment of mental disorders . ② can increase plasma levels of β-endorphin, block the pain impulse conduction through the spinal cord bundle network, the treatment of pain related.