目的深入了解侵袭性垂体腺瘤的生物学特性 ,提高其诊断、治疗水平。　方法对 5 4例患者 (非侵袭性垂体腺瘤组 31例 ,侵袭性垂体腺瘤组 2 3例 )的临床、病理、细胞增殖动力学三方面资料作差异显著性检验及相关性分析。　结果在临床方面 ,两组在病程、肿瘤大小、肿瘤组织坏死、卒中、囊变发生率、手术全切除率、术后复发率等方面有显著差异 (P <0 .0 5 )。病理学研究 ,两组在微血管定量方面有显著差异 (P <0 .0 5 )。肿瘤细胞的增殖指数 (PCNA指数和Ki- 6 7指数 ) ,侵袭性腺瘤显著大于非侵袭性腺瘤 (P <0 .0 1)。　结论侵袭性垂体腺瘤进展快 ,多为大腺瘤 ,肿瘤组织坏死、囊变、卒中发生率高 ,手术全切除率低 ,术后易复发 ,肿瘤血供较为丰富 ,肿瘤细胞增殖较快。 Objective To further understand the biological characteristics of invasive pituitary adenomas and improve their diagnosis and treatment. Methods The clinical, pathological and cell proliferation kinetics of 54 patients (31 non-invasive pituitary adenomas and 23 invasive pituitary adenomas) were tested for significant differences and correlation analysis. Results Clinically, there were significant differences in the duration of disease, tumor size, tumor tissue necrosis, stroke, cystic degeneration rate, total resection rate, and postoperative recurrence rate (P < 0.05). In the pathological study, there was a significant difference in microvascular quantification between the two groups (P < 0.05). Tumor cell proliferation index (PCNA index and Ki-67 index), invasive adenomas were significantly greater than non-invasive adenomas (P < 0.01). Conclusions The invasive pituitary adenomas progress rapidly, mostly large adenomas, with high necrosis, cystic degeneration, and stroke rates. The total resection rate is low, and postoperative recurrences are easy. The tumor blood supply is abundant and the tumor cells proliferate rapidly.