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为了确定白细胞介素2(IL-2)与γ干扰素(IFN-γ)结合使用的毒性和最大耐受剂量,作者进行了Ⅰ期临床试验。26例病人中,16例男性,10例女性,平均年龄为46岁(21～67岁)。分别患有肾细胞癌、恶性黑素瘤、结肠直肠癌等恶性肿瘤,大多数病人以前未进行过治疗或治疗时间很短。病人于每周1、3、5注射3次,IFN-γ剂量为0.05～0.25mg/m~2(1～4×10~6Um~2),IL-2剂量为0.33～2.33mg/m~2(6～42
To determine the toxicity and maximum tolerated dose of interleukin 2 (IL-2) in combination with gamma interferon (IFN-γ), the authors performed a phase I clinical trial. Of the 26 patients, 16 were males and 10 were females with an average age of 46 years (21 to 67 years). There are malignant tumors such as renal cell carcinoma, malignant melanoma, and colorectal cancer, respectively, and most patients have not been treated or treated for a short period of time. The patient received three injections of 1, 3, and 5 weekly, and the IFN-γ dose was 0.05 to 0.25 mg/m 2 (1 to 4×10 6 Um 2 ), and the IL-2 dose was 0.33 to 2.33 mg/m 2 . 2 (6 to 42