【摘 要】
：
To further expand an effective modified route for the shift from an antibacterial fluoroquinolone (FQ) to an antitumor FQ, two series of title compounds based o
【机 构】
：
Institute of Chemistry & Biology,China Pharmaceutical University
论文部分内容阅读
To further expand an effective modified route for the shift from an antibacterial fluoroquinolone (FQ) to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings, [l,2,4]triazolo[3,4-6][l,3,4]thiadiazine and pyrazolo[5,l-c][l,2,4]triazole, respectively, were designed and synthesized starting from the current antibacterial FQs, and their in vitro antitumor activity against L1210, CHO cell lines were evaluated via their respective IC50 values.
其他文献
Background The rodentia and lagomorpha animals are the intermediate hosts of Echinococcus multilocularis, their distribution and infection of this parasite may
The biosorption characteristics of Cs(I) ions from aqueous solution using exopolymers (PFC02) produced from Pseudomonas fluorescens C-2 were investigated as a f
在澳大利亚高等职业教育教学过程中,教学的依据、教师备课以及教学方法等方面体现了澳大利亚职业教育发展成果和独特之处.我国高等职业教育教学中的特点与之对比,存在着较大
目的探索开展中学生HIV/AIDS健康教育干预模式的效果。方法在深圳宝安区随机抽取8所中学学校,随机分为干预组和对照组(各4所),对干预组进行每月一次(共持续4个月)的HIV/AIDS
Facile synthesis of the two new natural heterocyclic compounds bretschneiderazines A (2) and B (3), isolated from an extract of the stems of Bretschneidera sine
A mild, efficient and high yielding protocol for the synthesis of 2,2'-arylmethelene dicyclohexane-1,3-dione derivatives at room temperature and 9-aryl-l,8-dihy
Melamine and poly vinylpyrrolidone (PVP) reacted with neat sulfuric acid readily to form two new organic solid acids namely melamine-(H2SO4)3 and PVP-(H2SO4)n.
Antimony (Sb) has received increasing environmental concerns due to its potential toxic and carcinogenic properties.In the present work,the electrocoagulation t
Various 2-phenylimidazo [4,5-f] [1,10] phenanthrolines were synthesized from potassium ferro-cyanide trihydrate (KFCT) complex catalyzed three component reactio
Synergistic removal of aniline by carbon nanotubes and the enzymes of Delftia sp.XYJ6,a newly isolated bacterial strain for biodegrading aniline,was investigate