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目的 探讨不同恶性程度胶质瘤中凋亡的作用和意义 .方法 应用 TUNEL 技术对 38例胶质瘤的凋亡表达及其意义进行了研究 .其中低恶性胶质瘤 2 0例 ,高恶性 18例 .结果 TUNEL 阳性细胞在各级别胶质瘤中均有表达 ,其在高分化的 ～ 级胶质瘤的阳性率 (凋亡指数 )明显低于 ～ 级胶质瘤 (2 .8± 0 .5 vs5 .6± 1.2 ,P<0 .0 1) ,其表达强度与胶质瘤的良、恶性程度明显相关 (P<0 .0 1) .结论 不同级别胶质瘤凋亡指数有明显差别 ,TU NEL法可辅助临床判断胶质瘤的良、恶性程度
Objective To investigate the role and significance of apoptosis in different malignant gliomas.Methods The expression of apoptosis in 38 gliomas and its significance were studied by TUNEL technique.Among them, 20 cases of low grade glioma, Results TUNEL positive cells were expressed in all grades of gliomas, and their positive rates (apoptotic index) in differentiated grade glioma were significantly lower than those in grade glioma (2. 8 ± 0. 5 vs5.6 ± 1.2, P <0.01), the expression intensity of which was significantly correlated with the degree of malignancy of glioma (P <0.01) .Conclusion The apoptotic index of different grades of glioma is obviously different , TU NEL method can help clinical judgment glioma benign and malignant degree