本文采用小鼠骨髓微核试验法,以计数多染红细胞微核率(‰)为指标,对植物黄酮类成分槲皮素及芦丁进行了实验研究。结果表明:槲皮素及芦丁无明显致突变作用,微核率无明显增加。槲皮素剂量为100、150mg/kg时对环磷酰胺的致突变作用显示一定的抑制,微核率明显减少。 In this paper, mouse bone marrow micronucleus test method was used to count the micronuclear rate (多) of polychromatic erythrocytes as an indicator. Experimental studies were conducted on the flavonoids quercetin and rutin. The results showed that quercetin and rutin had no obvious mutagenic effect, and the micronucleus rate did not increase significantly. When the quercetin dose was 100, 150 mg/kg, the mutagenic effect of cyclophosphamide showed some inhibition, and the micronucleus rate was significantly reduced.