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以往研究显示,在感染丝虫的长爪沙鼠中,特异性免疫应答的降低要有活的成虫而并非依赖微丝蚴诱导或维持这种现象。为了进一步阐明是生活史哪一期引起丝虫的低应答性反应,作者采用布鲁属丝虫三期幼虫(L_3)经15,25,35,45,90Kradγ射线照射后,通过腹腔感染长爪沙鼠,于接种后7,14,28,118天进行解剖,同时设立了未经照射感染组和未感染组为对照。对虫体的发育、腹腔内炎性反应的程度和肺部炎性肉芽肿(PGRN)进行检测。 结果显示,γ射线可抑制丝虫的发育并减少虫体存活率。接种后7天,虫体长度与对
Previous studies have shown that the reduction of specific immune responses in live-worm gerbils infected with filariasis requires the presence of viable adults rather than the induction or maintenance of this phenomenon by microfilaria. In order to further clarify which phase of life history caused the low response of filarial worms, the authors adopted the third instar larvae of Lactobacillus sibiricum (L_3) irradiated by 15, 25, 35, 45, 90Krad gamma rays, Gerbils were dissected 7, 14, 28, and 118 days after inoculation, and the control group was set up as non-irradiated group and uninfected group. Insect development, intraperitoneal inflammatory response and pulmonary inflammatory granuloma (PGRN) were examined. The results showed that γ ray can inhibit the development of filarial and reduce the survival rate of parasites. 7 days after inoculation, parasites length and right